The 87-year-old comedian-actor walked out to thunderous applause after the screening Saturday, joining co-star Robert De Niro and director Martin Scorsese.
Lewis answered questions about the making of the film and brought the audience to laughter with a tale about a guy he met on a subway train.
In the movie, Lewis plays a talk show host kidnapped by a deranged comedian played by De Niro.
De Niro founded the festival with producers Jane Rosenthal and Craig Hatkoff as a way to rebuild the neighborhood where the World Trade Center fell in the 9/11 attacks.
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